Metformin has anti-carcinogenic properties and is also known to inhibit the Sonic hedgehog pathway, but no population-based studies exist analyzing the potential protective effect for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

Patients with psoriasis and psoriatic arthritis who received methotrexate were more likely to develop liver disease compared to patients with rheumatoid arthritis, independent of other major risk factors, Conservative hepatotoxicity monitoring may be warranted in patients receiving methotrexate for psoriatic…